Guiding you through early drug discovery
The typical drug development pipeline consists of several phases. Here at Helix BioStructures, we specialize in the early drug discovery phase and provide a dedicated focus in therapeutic discovery, physical characterization, protein synthesis, and related software development. The discovery phase of drug development centers on investigating small molecules (traditional pharmaceuticals or drugs) and protein (large molecules) based therapies such as antibodies. Our expertise encompasses drug design and development, chemical and structural analysis, protein production and purification, and computational modeling and design. This knowledge base allows us to assist you in several ways:
A full suite of structural biology resources to analyze and determine the composition and configuration of therapeutic molecules
In-house production facilities to synthesize proteins with a given specificity and purity
Computational protein-ligand docking and analysis to aid in the elucidation and refinement of drug design
Our focus is the discovery phase of the drug development timeline
Target selection
- Proteomic analysis
- Protein target synthesis
- Virtual compound screening
Lead discovery
- Computational drug design
- Drug molecule docking
- Fragment-based drug design
- Biophysical analysis
Structural studies
- X-ray crystallography
- Cryo-EM
- Micro-ED
- Bio-SAXS
Target validation
- In-vitro testing
Pharmacology
- Protein target synthesis
- Biophysical analysis
- Structure-activity relationship studies