LNP Characterization
Helix's cryo-EM team brings specialized expertise in the structural characterization of liposomes and lipid nanoparticles.
Comprehensive Services
We provide customers with an end-to-end service that is customized to bring the project to success and typically includes LNP sample preparation, data collection, and data analysis.
Cutting-Edge Techniques
We provide services for three of the most effective characterization techniques for LNPs: Cryo-EM, SAXS, and DLS.
Rapid Turnaround Times
Our well-optimized workflows enable you to get the information
you require at the right time, thereby accelerating your research.
Your Partner in Discovery
Please do not hesitate to contact us and find out how our Cryo-EM, SAXS and DLS services can support your innovative LNP-based therapeutics. Helix BioStructures is happy to be your partner in the development of novel drug delivery systems.
Technique-based LNP Services
Cryo-EM: Visualizing LNPs with Unparalleled Detail
Cryo-Electron Microscopy offers high-resolution structural insights, providing critical information about LNP morphology and particle integrity.
- Data Collection: 1 week
- Outcome: Detailed structural snapshots that guide formulation optimization and stability assessment.
SAXS: Gaining Insights into Size and Shape
Small Angle X-ray Scattering excels at elucidating the overall size, shape, and assembly properties of your LNPs in solution.
- Data Collection: 1 week
- Analysis: 1–2 weeks
- Outcome: Quantitative profiles that enable you to fine-tune particle dimensions and enhance therapeutic performance.
DLS: Rapid Quality Control for Particle Size
Dynamic Light Scattering provides a fast and reliable measure of particle size distribution and polydispersity.
- Data Collection & Analysis: < 1 week
- Outcome: Timely verification of homogeneity and stability—essential for robust LNP formulations.
Never feel lost in the process again
LNPs have become an essential delivery mechanism for RNA and other molecules in the pharmaceutical and agricultural industries. Characterizing LNPs allows researchers to develop and produce the most effective platform for delivering their next-generation molecules in an industrially efficient manner. At Helix, we offer in-depth knowledge and a multi-technique characterization approach for your LNP formulations.
"We have consistently been impressed by Helix's expertise, quality, speed, and thoughtfulness throughout our work together. They have proven to be an ideal partner in our structural biology projects, consistently delivering impressive results and maintaining excellent communication every step of the way."
"Helix Biostructures has been delivering exceptional protein production and characterization services to us in the agricultural biotechnology sector. Our work together is defined by a shared dedication to excellence and an in-depth knowledge of the international regulations and standards necessary for the deregulation of biotechnological crops. Our collaboration makes a substantial contribution to our clients' endeavors in sustainably offering biotechnological solutions for crop protection and increased production."
"Collaborating with Helix to elucidate the structure of our therapeutic antibody in complex with its antigen through Cryo-EM was very valuable for our research. Their expertise in protein sciences and structural biology gave us detailed insights into the antibody-antigen allosteric mechanism, advancing our understanding significantly. The data they provided exceeded our expectations and contributed to the publication of a high-impact paper. The professionalism and technical skill of their team made the entire process smooth and efficient."
"We were highly impressed with Helix BioStructures, who provided a swift collection and analysis of our SAXS samples. Their clear communication and willingness to accommodate specialized handling was invaluable to the success of our experiment."
